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For each divergence distance and each tool, 1,000 replicates were used to calculate the mean and standard error of constraint coverage and constraint sensitivity, which were defined as the coverage and sensitivity within interspersed constrained blocks (see Methods for details). A) constraint coverage without insertion/deletion evolution; B) constraint coverage with insertion/deletion evolution; C) constraint sensitivity without insertion/deletion evolution; D) constraint sensitivity with insertion/deletion evolution.
Please note that this figure has been updated since publication and corresponds to figure 3 in the erratum.
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